http://theloislab.com/work daily 1.0 2019-06-04 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1559689573668-JUIZ5JZCHH5EE9DIH24Y/just%2Btop22.jpg About http://theloislab.com/researcharea daily 0.75 2024-12-05 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1484671718806-F77LSFLCETO5ESWXEZA9/Sonogram+for+Daniel.jpg Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1486436294340-23F3LSVGLVAPF0L19PW7/tracee.png Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1486482929882-WEI8LKRKG89OC5N5BKS3/SUM_121516+Rt+AD28+AOB+AB3080P.2.jpg Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1486483146564-HQXAMK2J8PFLDSVRL7VB/SUM_121516+Rt+AD28+AOB+AB3080P.2.jpg Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1513288559865-JSFKSZJY5HZ04ZKMG037/psyched+glom.jpg Research http://theloislab.com/new-cover-page daily 0.75 2016-12-12 http://theloislab.com/people daily 0.75 2026-03-09 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1739559810449-5OKM6XEA0C1C4XMTMYUK/group+foto+cropped.jpg PEOPLE https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481182074614-VYL5RX0JSFHD12XAQHWG/IMG_4974.JPG PEOPLE https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/c6894ef9-28cb-4558-b17d-79dacbedb67a/Jiahui.jpg PEOPLE - Jiahui Peng grew up in Xi’an, China, and spent her happy undergraduate years in Peking University, School of Life Sciences. She is charmed by the mechanisms nature has evolved in the neural system to support amazing functions such as learning and memory. In the Lois lab, she studies the neural basis of singing behavior in song birds. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/94c209c4-4dee-47fa-bd9d-57b7b182bc0f/Jiang%282%29.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1b273a98-77b8-4b1f-aba1-1877227a90e7/Loizidou_headshot.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/41671e5c-fb1d-4d2a-89ff-49f15540df78/thumbnail_IZLL_Picture.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481183117604-6LYB9EKNIAIQ413CTXD5/image-asset.jpeg PEOPLE https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/25946ff9-73fb-4d27-a734-7145587cea62/thumbnail_IMG_3088.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481183638534-2YNQH27HG64LXT3BONX3/IMG_4967.JPG PEOPLE https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/45d64567-bfd4-427f-9189-68d0a94ba2e6/thumbnail_Nicole+S.jpg PEOPLE - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://theloislab.com/new-page daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481014347020-KK8LK8YTNOYLD41MWAMZ/image-asset.jpeg Contact http://theloislab.com/research daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012262583-EKPTGXEUG3NM5NLC9COK/image-asset.png Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012289827-FA5LVV30LTH9ZH2LI4ES/research7.png Research https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012433373-Q8A39DMEKZN10495KSA5/image001.png Research http://theloislab.com/welcome daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/5052176b84aeb45fa5cfcc83/1349577199654-C8A6HP2M4MLEBJXQ06MF/wilderness.png Welcome - Transient http://theloislab.com/genetic-control-of-the-assembly-of-circuits-involved-in-vocal-learning daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481013058887-3IMKOC7HZZKUPI9BC1MP/research5.png Genetic control of the assembly of circuits involved in vocal learning. Genetically modified songbirds to investigate the molecular bases of vocal learning and complex behavior. Our lab has developed several techniques to genetically manipulate the development and function of neurons during the assembly of neuronal circuits. We have recently developed new genetic methods that have allowed us to generate transgenic songbirds to investigate the genetic basis of the assembly of brain circuits involved in vocal communication. We are using these transgenic songbirds to investigate the rules by which neurons migrate, choose their final locations, establish connections with each other, and give rise to behavior. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481013087375-CGOJXUJG24N07V8OCVXL/image-asset.png Genetic control of the assembly of circuits involved in vocal learning. Transgenic songbirds with a targeted mutation for the autism-related gene CNTNAP2. We have generated transgenic songbirds targeting the autism-related gene CNTNAP2 and have observed that the mutant birds fail to accurately copy their tutor’s song. (Bottom right) Wild-type siblings copy the song of their fathers very accurately, but mutant birds fail to copy the parts of the song that are acoustically complex. We are investigating how perturbation of CNTNAP2 affects the assembly of brain circuits involved in learning and production of songs. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481013118843-E8R8OKHQF4ZSW8C98YEL/image-asset.png Genetic control of the assembly of circuits involved in vocal learning. Genetic manipulation of activity and robustness of behavior. We have observed that delivering a voltage-gated sodium channel to render neurons in the song system hyperexcitable leads to acute degradation of the song. Surprisingly, the song structure recovers very quickly (within 10 days) after the genetic manipulations. We are currently investigating the mechanisms responsible for this recovery. http://theloislab.com/welcome-to-the-lois-lab daily 0.75 2016-12-08 http://theloislab.com/publications daily 0.75 2016-12-08 http://theloislab.com/hire-us daily 0.75 2017-01-18 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481616452470-UA81OUTNWWADQJBYHGAS/Untitled_HDR2.jpg Contact http://theloislab.com/regulation-of-neuronal-integration-into-brain-circuits daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012886726-P1DSSE27KUH6QWOXWKIB/image-asset.png Regulation of neuronal integration into brain circuits. Commitment of stem cells to the production of neurons with defined connectivity. Stem cells located in the subventricular zone (SVZ) of adult mice are committed to generate the same neuronal type (granule cells in the olfactory bulb with defined connectivity. Stem cells located in the anterior regions of the SVZ (labeled in red) produce neurons whose dendrites reach the upper layers of the olfactory bulb. In contrast, stem cells located in the posterior SVZ (labeled in green) produce neurons whose dendrites branch in the lower layers of the OB. Our laboratory is investigating the molecules that regulate the patterns of connectivity of neurons in this brain region. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012534559-MZDHFAQAAIQK9IUCRHIW/image-asset.png Regulation of neuronal integration into brain circuits. Regulation of synaptic connections by intrinsic electrical activity. Newly-generated neurons (green) in adult mice are rendered hyperexcitable by delivering into them Nachbac, a voltage-gated sodium channel, via recombinant retroviruses. (Bottom) Genetically-enhanced excitability increases the number of inhibitory synapses (arrows) on the genetically modified neurons (green). By genetically controlling the electrical properties of neurons we investigate how neuronal activity regulates the integration of cells into brain circuits, and the connections between neurons. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012560239-YSD7JADBZWSAMZ5VZPMI/image-asset.png Regulation of neuronal integration into brain circuits. Subcellular distribution of synaptic inputs and integration of neurons into circuits (left) Granule cells in the olfactory bulb have neurotransmitter receptors in the apical (top) and basal (bottom) dendrites. Recent evidence suggests that the inputs directed to the apical dendrites favors the survival and integration of new neurons into the bulb. In contrast, the input directed towards the basal dendrites impairs the integration of new neurons. We are currently investigating the molecular basis for this differential effect of these 2 subcellular compartments on the neuron’s survival. https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481012575466-ZPJMPJSMX1VPNWOI3W3M/image-asset.png Regulation of neuronal integration into brain circuits. Action potentials regulate the maturation of synaptic inputs. We have recently generated reagents that allow us to genetically block action potentials in individual neurons. We have observed that neurons without action potentials (left bottom) survive and integrate into the brain, but they fail to receive synaptic input (right bottom). We are investigating the mechanisms by which intrinsic neuronal activity regulates the formation and functional maturation of synapses. http://theloislab.com/a-new-genetic-method-to-identify-connectivity-between-neurons daily 0.75 2016-12-06 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1481013219156-B5KZTK2X111724BLH6NQ/research8.png A new genetic method to identify connectivity between neurons. A new genetic method to identify connectivity between neurons. We have designed a new genetic strategy to identify the wiring diagram of brain circuits. The system is based on the logic of the delta-notch system and it will allows not only to trace connections between neurons, but also to genetically modify the physiological properties of circuits of connected neurons. http://theloislab.com/publications-1 daily 0.75 2025-10-23 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1486626239048-SM3SKR5HR069XYSP8PNK/PNAS-2005-Scott-16443-7-3.png Publications http://theloislab.com/join daily 0.75 2019-06-04 http://theloislab.com/tract-limitations-and-troubleshooting-1 daily 0.75 2018-02-13 https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517601226136-TOROMOJGVMQHXVJPUFW9/Screen+Shot+2018-02-01+at+12.17.10+PM.png TRACT: limitations and troubleshooting - TRACT: Tips, Troubleshooting & Limitations   https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517531383705-15YYWWIDAP5AL3TXD76S/Screen+Shot+2018-02-01+at+4.29.32+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517449829940-FCSDYR2UJ7GV6TXIEM3K/Screen+Shot+2018-01-31+at+5.04.27+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517449889650-XY6MNEHJ4XZ1LSHED9Y2/Screen+Shot+2018-01-31+at+5.05.54+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517602654662-GYLUKC4CI9VG3XWY3PW9/Screen+Shot+2018-02-02+at+12.09.23+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517449393006-NJZNBG757LR6K7XN1YPU/Screen+Shot+2018-01-31+at+4.39.28+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517449489695-6GFDNAENVGH7VJFTL3LD/Screen+Shot+2018-01-31+at+4.47.31+PM.png TRACT: limitations and troubleshooting https://images.squarespace-cdn.com/content/v1/58462b3b197aeac7d8af6bad/1517449645286-4TB2L6OQZI2EZB9IMG09/Screen+Shot+2018-01-31+at+4.49.38+PM.png TRACT: limitations and troubleshooting http://theloislab.com/read-me daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/5310cef7e4b08602cbfa36bf/1412689652885-P9TPK298WCTZU748L0SG/Lifestyle03.jpg Read Me