Projection neurons are necessary for the maintenance of the mouse olfactory circuit.
Luis Sánchez-Guardado, Peyman Razavi, Bo Wang, Antuca Callejas-Marín, Carlos Lois. Elife. October 28, 2024. https://doi.org/10.7554/eLife.90296.2
Unsupervised restoration of a complex learned behavior after large-scale neuronal perturbation.
Wang B, Torok Z, Duffy A, Bell DG, Wongso S, Velho TAF, Fairhall AL, Lois C. Nat Neurosci. 2024 Jun;27(6):1176-1186. doi: 10.1038/s41593-024-01630-6. Epub 2024 Apr 29. PMID: 38684893
Human cerebellar organoids with functional Purkinje cells.
Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, Paul S, Tedeschi N, Taylor R, Coba MP, Samarasinghe R, Lois C, Quadrato G. Cell Stem Cell. 2024 Jan 4;31(1):39-51.e6. doi: 10.1016/j.stem.2023.11.013. PMID: 38181749
Engineering RNA export for measurement and manipulation of living cells.
Horns F, Martinez JA, Fan C, Haque M, Linton JM, Tobin V, Santat L, Maggiolo AO, Bjorkman PJ, Lois C, Elowitz MB. Cell. 2023 Jul 10:S0092-8674(23)00689-X. doi: 10.1016/j.cell.2023.06.013. Online ahead of print. PMID: 37437570
Torok Z, Luebbert L, Feldman J, Duffy A, Nevue AA, Wongso S, Mello CV, Fairhall A, Pachter L, Gonzalez WG, Lois C. bioRxiv. 2023 May 23:2023.05.17.541057. doi: 10.1101/2023.05.17.541057. Preprint. PMID: 37292888
Embryo-scale, single-cell spatial transcriptomics.
Srivatsan SR, Regier MC, Barkan E, Franks JM, Packer JS, Grosjean P, Duran M, Saxton S, Ladd JJ, Spielmann M, Lois C, Lampe PD, Shendure J, Stevens KR, Trapnell C. Science. 2021 Jul 2;373(6550):111-117. doi: 10.1126/science.abb9536. PMID: 34210887
Velho TAF, Lovell PV, Friedrich SR, Olson CR, Miles J, Mueller PA, Tavori H, Fazio S, Lois C, Mello CV. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2025167118. doi: 10.1073/pnas.2025167118. PMID: 33903244
Imaging cell lineage with a synthetic digital recording system.
Chow KK, Budde MW, Granados AA, Cabrera M, Yoon S, Cho S, Huang TH, Koulena N, Frieda KL, Cai L, Lois C, Elowitz MB. Science. 2021 Apr 9;372(6538):eabb3099. doi: 10.1126/science.abb3099. PMID: 33833095
Li Y, Gonzalez WG, Andreev A, Tang W, Gandhi S, Cunha A, Prober D, Lois C, Bronner ME. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27400-27411. doi: 10.1073/pnas.2007229117. Epub 2020 Oct 21. PMID: 33087579
Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. Nat Biotechnol. 2020 Feb;38(2):245. doi: 10.1038/s41587-020-0432-4. PMID: 31988471
In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription.
Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. Nat Biotechnol. 2020 Jan;38(1):66-75. doi: 10.1038/s41587-019-0299-4. Epub 2019 Nov 18. PMID: 31740838
Persistence of neuronal representations through time and damage in the hippocampus. Gonzalez WG, Zhang H, Harutyunyan A, Lois C. Science. 2019 Aug 23;365(6455):821-825.
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Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb. Sanchez-Guardado, LS and Lois C. Elife 2019;8:e46675
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Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK.Cell. 2019 May 30;177(6):1600-1618.e17. doi: 10.1016/j.cell.2019.05.004.
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In Vivo Quantitative Imaging Provides Insights into Trunk Neural Crest Migration. Li Y, Vieceli FM, Gonzalez WG, Li A, Tang W, Lois C, Bronner ME. Cell Rep. 2019 Feb 5;26(6):1489-1500.e3.
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Hierarchical neural architecture underlying thirst regulation. Augustine V, Gokce SK, Lee S, Wang B, Davidson TJ, Reimann F, Gribble F, Deisseroth K, Lois C, Oka Y. Nature. 2018 Mar 8;555(7695):204-209.
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Tracing neuronal circuits in transgenic animals by transneuronal control of transcription (TRACT). Huang TH, Niesman P, Arasu D, Lee D, De La Cruz A, Callejas A, Hong EJ, Lois C. Elife. 2017 Dec 12;6. pii: e32027. doi: 10.7554/eLife.32027.
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Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V. Nat Neurosci. 2017 Aug;20(8):1172-1179. doi: 10.1038/nn.4593. Epub 2017 Jun 26. PMID: 28671695.
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Methods to investigate the structure and connectivity of the nervous system. Lee D, Huang TH, De La Cruz A, Callejas A, Lois C. Fly (Austin). 2017 Jul 3;11(3):224-238. doi: 10.1080/19336934.2017.1295189. Epub 2017 Feb 16.
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Unstable neurons underlie a stable learned behavior. Liberti WA 3rd, Markowitz JE, Perkins LN, Liberti DC, Leman DP, Guitchounts G, Velho T, Kotton DN, Lois C, Gardner TJ. Nat Neurosci. 2016 Dec;19(12):1665-1671. doi: 10.1038/nn.4405. View in: PubMed
Monitoring cell-cell contacts in vivo in transgenic animals. Huang TH, Velho T, Lois C. Development. 2016 Nov 1;143(21):4073-4084.
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Determination of the connectivity of newborn neurons in mammalian olfactory circuits. Ravi N, Sanchez-Guardado L, Lois C, Kelsch W. Cell Mol Life Sci. 2016 Sep 30,
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A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types. Shima Y, Sugino K, Hempel CM, Shima M, Taneja P, Bullis JB, Mehta S, Lois C, Nelson SB. Elife. 2016 Mar 21;5. pii: e13503.
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Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. Wu X, Zhang Y, Takle K, Bilsel O, Li Z, Lee H, Zhang Z, Li D, Fan W, Duan C, Chan EM, Lois C, Xiang Y, Han G. ACS Nano. 2016 Jan 26;10(1):1060-6.
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FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons. Bosch C, Martínez A, Masachs N, Teixeira CM, Fernaud I, Ulloa F, Pérez-Martínez E, Lois C, Comella JX, DeFelipe J, Merchán-Pérez A, Soriano E. Front Neuroanat. 2015 May 21;9:60.
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Mesoscopic patterns of neural activity support songbird cortical sequences. Markowitz JE, Liberti WA 3rd, Guitchounts G, Velho T, Lois C, Gardner TJ. PLoS Biol. 2015 Jun 3;13(6):e1002158.
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Generation of transgenic zebra finches with replication-deficient lentiviruses. Velho TA, Lois C. Cold Spring Harb Protoc. 2014(12):1284-9
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Adult neurogenesis and its promise as a hope for brain repair. Lois C, Kelsch W. Front Neurosci. 2014; 8:165.
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Increased cell-intrinsic excitability induces synaptic changes in new neurons in the adult dentate gyrus that require Npas4. Sim S, Antolin S, Lin CW, Lin Y, Lin YX, Lois C. J Neurosci. 2013 May 1; 33(18):7928-40.
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Similarity of visual selectivity among clonally related neurons in visual cortex. Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K. Neuron. 2012 Jul 12; 75(1):65-72.
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Genetic labeling of neuronal subsets through enhancer trapping in mice. Kelsch W, Stolfi A, Lois C. PLoS One. 2012; 7(6):e38593.
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Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats. Kelsch W, Sim S, Lois C. J Comp Neurol. 2012 Apr 15; 520(6):1327-38.
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Coincident generation of pyramidal neurons and protoplasmic astrocytes in neocortical columns. Magavi S, Friedmann D, Banks G, Stolfi A, Lois C. J Neurosci. 2012 Apr 4; 32(14):4762-72.
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Wandering neuronal migration in the postnatal vertebrate forebrain. Scott BB, Gardner T, Ji N, Fee MS, Lois C. J Neurosci. 2012 Jan 25; 32(4):1436-46.
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Genetics in non-genetic model systems. Lois C, Groves JO. Curr Opin Neurobiol. 2012 Feb; 22(1):79-85.
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Genetically increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits. Lin CW, Sim S, Ainsworth A, Okada M, Kelsch W, Lois C. Neuron. 2010 Jan 14; 65(1):32-9.
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Applications of avian transgenesis. Scott BB, Velho TA, Sim S, Lois C. ILAR J. 2010; 51(4):353-61.
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Watching synaptogenesis in the adult brain. Kelsch W, Sim S, Lois C. Annu Rev Neurosci. 2010; 33:131-49. View in: PubMed
Transgenic songbirds offer an opportunity to develop a genetic model for vocal learning. Agate RJ, Scott BB, Haripal B, Lois C, Nottebohm F. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17963-7. View in: PubMed
A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis. Kelsch W, Lin CW, Mosley CP, Lois C. J Neurosci. 2009 Sep 23; 29(38):11852-8. View in: PubMed
Transplanted neurons form both normal and ectopic projections in the adult brain. Magavi SS, Lois C. Dev Neurobiol. 2008 Dec; 68(14):1527-37. View in: PubMed
Sequential development of synapses in dendritic domains during adult neurogenesis. Kelsch W, Lin CW, Lois C. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16803-8. View in: PubMed
Genetic strategy to prevent influenza virus infections in animals. Chen J, Chen SC, Stern P, Scott BB, Lois C. J Infect Dis. 2008 Feb 15; 197 Suppl 1:S25-8. View in: PubMed
Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. Kelsch W, Mosley CP, Lin CW, Lois C. PLoS Biol. 2007 Nov; 5(11):e300. View in: PubMed
Developmental origin and identity of song system neurons born during vocal learning in songbirds. Scott BB, Lois C. J Comp Neurol. 2007 May 10; 502(2):202-14. View in: PubMed
Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Rivera FJ, Couillard-Despres S, Pedre X, Ploetz S, Caioni M, Lois C, Bogdahn U, Aigner L. Stem Cells. 2006 Oct; 24(10):2209-19. View in: PubMed
Generation of transgenic birds with replication-deficient lentiviruses. Scott BB, Lois C. Nat Protoc. 2006; 1(3):1406-11. View in: PubMed
Generation of tissue-specific transgenic birds with lentiviral vectors. Scott BB, Lois C. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16443-7. View in: PubMed
Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testis. Nakagawa T, Feliu-Mojer MI, Wulf P, Lois C, Sheng M, Hoogenraad CC. J Neurosci Methods. 2006 Apr 15; 152(1-2):1-9. View in: PubMed
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez-Buylla A. Nature. 2003 Oct 30; 425(6961):968-73. View in: PubMed
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D. Science. 2002 Feb 1; 295(5556):868-72. View in: PubMed
Retroviruses as tools to study the immune system. Lois C, Refaeli Y, Qin XF, Van Parijs L. Curr Opin Immunol. 2001 Aug; 13(4):496-504. View in: PubMed
Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb. Kirschenbaum B, Doetsch F, Lois C, Alvarez-Buylla A. J Neurosci. 1999 Mar 15; 19(6):2171-80. View in: PubMed
Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain. Yoon SO, Lois C, Alvirez M, Alvarez-Buylla A, Falck-Pedersen E, Chao MV. A Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11974-9. View in: PubMed
Lois C, García-Verdugo JM, Alvarez-Buylla A. Chain migration of neuronal precursors. Science. 1996 Feb 16; 271(5251):978-81. View in: PubMed
Neuronal stem cells in the brain of adult vertebrates. Alvarez-Buylla A, Lois C. Stem Cells. 1995 May; 13(3):263-72. View in: PubMed
Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice. Rousselot P, Lois C, Alvarez-Buylla A. J Comp Neurol. 1995 Jan 2; 351(1):51-61. View in: PubMed
Long-distance neuronal migration in the adult mammalian brain. Lois C, Alvarez-Buylla A. Science. 1994 May 20; 264(5162):1145-8. View in: PubMed
Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Lois C, Alvarez-Buylla A. Proc Natl Acad Sci U S A. 1993 Mar 1; 90(5):2074-7. View in: PubMed